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Application of Toxicogenomics to Cross-Species Extrapolation: A Report of a Workshop

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Application of Toxicogenomics to Cross-Species Extrapolation: A Report of a Workshop

4.85 32,234 ratings · 3,602 reviews
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Overview: Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression (transcriptomics), proteins (proteomics) and metabolites (metabolomics), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.

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Pages 58
Publisher National Academies Press
Published May 14, 2014
ISBN 22868243
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Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
About the Author
Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
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Committee on Applications of Toxicogenomics to Cross-Species Extrapolation is the author of several novels. Originally from the East Coast, they now live in the Midwest with family. In addition to writing, Committee on Applications of Toxicogenomics to Cross-Species Extrapolation enjoys gardening, cooking, and reading way past bedtime. Their work often explores the complexities of everyday life and human relationships.

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A highly sophisticated read. The middle had a deliberate pace, but the climax was phenomenal. A very distinguished novel.
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Exceeded all my expectations. It strikes a perfect harmony of dialogue and world-building. Every chapter felt necessary. I will undoubtedly revisit this masterpiece.
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I was completely blown away. I adored how the story unfolded. It kept me captivated without sacrificing elegance. Worth every moment spent reading.
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A profoundly satisfying read. I became deeply invested in the protagonist's journey. A masterclass in storytelling. I will undoubtedly revisit this masterpiece.
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Exceeded all my expectations. The pacing was impeccable and the characters felt incredibly authentic. I was completely immersed. Worth every moment spent reading.
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Masterpiece from start to finish. The prose is exquisite. It’s accessible yet undeniably sophisticated. A true literary gem.
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A profoundly satisfying read. The author orchestrated a breathtaking finale. Truly a work of art. I will undoubtedly revisit this masterpiece.
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Absolutely brilliant. I became deeply invested in the protagonist's journey. A masterclass in storytelling. An absolute must-read for connoisseurs of the genre.
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Edward Martin
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John Turner
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